SUBTITLE C: WATER POLLUTION
CHAPTER I: POLLUTION CONTROL BOARD
PART 302 WATER QUALITY STANDARDS
SECTION 302.590 PROCEDURES FOR DETERMINING THE LAKE MICHIGAN BASIN HUMAN HEALTH NONTHRESHOLD CRITERION (LMHHNC) OR THE LAKE MICHIGAN BASIN HUMAN HEALTH NONTHRESHOLD VALUE (LMHHNV)
Section 302.590 Procedures for Determining the Lake Michigan Basin Human Health Nonthreshold Criterion (LMHHNC) or the Lake Michigan Basin Human Health Nonthreshold Value (LMHHNV)
A LMHHNC or LMHHNV shall be derived for those toxic substances for which any exposure, regardless of extent, carries some risk of damage from cancer or a nonthreshold toxic mechanism. For single or combinations of substances, a risk level of 1 in 100,000 (or 10(-5)) shall be used for the purpose of determination of a LMHHNC or LMHHNV.
a) Minimum data requirements. Minimal experimental or epidemiological data requirements are incorporated in the cancer classification determined by USEPA at Appendix C II A to 40 CFR 132, incorporated by reference at Section 302.510.
b) Principles for development of criteria or values:
1) Animal data are fitted to a linearized multistage computer model (Global 1986 in "Mutagenicity and Carcinogenicity Assessment for 1,3-Butadiene" September 1985 EPA/600/8-85/004A, incorporated by reference at Section 301.106 or scientifically justified equivalents). The upper-bound 95 percent confidence limit on risk at the 1 in 100,000 risk level shall be used to calculate a risk associated dose (RAD); and
2) A species scaling factor shall be used to account for differences between test species and humans. Milligrams per surface area per day is an equivalent dose between species. All doses presented in mg/kg bodyweight will be converted to an equivalent surface area dose by raising the mg/kg dose to the 3/4 power.
c) Determining the risk associated dose (RAD). The RAD shall be calculated using the following equation:
RAD = 0.00001 / q1*
Where:
|
RAD |
= |
risk associated dose in milligrams of toxicant or combinations of toxicants per kilogram body weight per day (mg/kg/day) |
|
0.00001 (1 X 10-5) |
= |
incremental risk of developing cancer equal to 1 in 100,000 |
|
q1* |
= |
slope factor (mg/kg/day)-1 |
RAD = risk associated dose in milligrams of toxicant or combinations of toxicants per kilogram body weight per day (mg/kg/day)
0.00001 (1 X 10(-5)) = incremental risk of developing cancer equal to 1 in 100,000
q1* = slope factor (mg/kg/day)-1
d) Determining the Lake Michigan Basin Human Health Nonthreshold Criterion (LMHHNC) or the Lake Michigan Basin Human Health Nonthreshold Value (LMHHNV):
LMHHNC or LMHHNV =
{ RAD x BW } / { WC + [(FCTL3 x BAFHHTL3) + (FCTL4 x BAFHHTL4)] }
Where:
|
LMHHNC or LMHHNV is in milligrams per liter (mg/L) |
||
|
RAD |
= |
risk associated dose of a substance or combination of substances in milligrams per day (mg/d) which is associated with a lifetime cancer risk level equal to a ratio of 1 to 100,000 |
|
BW |
= |
weight of an average human (BW = 70 kg) |
|
WC |
= |
per capita water consumption for surface waters classified as public water supplies = two liters/day, or per capita incidental daily water ingestion for surface waters not used as human drinking water sources = 0.01 liters/day |
|
FCTL3 |
= |
mean consumption of trophic level 3 of regionally caught freshwater fish = 0.0036 kg/day |
|
FCTL4 |
= |
mean consumption of trophic level 4 of regionally caught freshwater fish = 0.0114 kg/day |
|
BAFHHTL3, BAFHHTL4 |
= |
bioaccumulation factor for trophic levels 3 and 4 as derived in Section 302.570 |
(Source: Added at 22 Ill. Reg. 1356, effective December 24, 1997)